Effectiveness of sulforaphane as a radiosensitizer for murine osteosarcoma cells

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Effectiveness of sulforaphane as a radiosensitizer for murine osteosarcoma cells.

Sulforaphane (SFN), a naturally occurring member of the isothiocyanate family, is effective against various types of malignant tumor cells. We studied whether the combination of SFN and radiation would be more effective against osteosarcoma cells when compared to these treatments alone. LM8 murine osteosarcoma cells were cultured with various conc...

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Sulforaphane induces cell cycle arrest and apoptosis in murine osteosarcoma cells in vitro and inhibits tumor growth in vivo.

Sulforaphane (SFN), a naturally occurring isothiocyanate, is an attractive agent due to its potent anticancer effects. SFN suppresses the proliferation of various cancer cells in vitro and in vivo. In this study, we report that SFN inhibited the proliferation of cultured murine osteosarcoma LM8 cells. Twenty micromolar SFN completely inhibited the growth of LM8 cells and caused G2/M-phase arres...

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ژورنال

عنوان ژورنال: Oncology Reports

سال: 2012

ISSN: 1021-335X,1791-2431

DOI: 10.3892/or.2012.2195